apixaban lv thrombus | apixaban vs warfarin lv thrombus apixaban lv thrombus Our results suggest that apixaban is non-inferior to warfarin for treatment of patients with LV thrombus after acute MI with a 20% non-inferiority margin. www.draugiem.lv;
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Our results suggest that apixaban is non-inferior to warfarin for treatment of patients with LV thrombus after acute MI with a 20% non-inferiority margin.
Apixaban versus warfarin in patients with left ventricular thrombus: a pilot prospective randomized outcome blinded study investigating size reduction or resolution of left ventricular thrombus. J Clin Prev Cardiol 2020;9:150–4. Our results suggest that apixaban is non-inferior to warfarin for treatment of patients with LV thrombus after acute MI with a 20% non-inferiority margin. Apixaban versus warfarin in patients with left ventricular thrombus: a pilot prospective randomized outcome blinded study investigating size reduction or resolution of left ventricular thrombus. J Clin Prev Cardiol 2020;9:150–4. Of the 514 patients with LV thrombi, 300 received warfarin, while 185 received DOAC therapy. DOAC use was most commonly apixaban (141/185, 76.2%) or rivaroxaban (46/185, 24.9%). Median follow-up was 351 days (interquartile range, [IQR], 51-866 days).
Keywords: Apixaban, direct oral anticoagulants, DOACs, left ventricular thrombus, Rivaroxaban, thrombolysis. 1. BACKGROUND. Left ventricular thrombus (LVT) is a common complication following acute myocardial infarction (AMI) with potential for significant morbidity and mortality.
Direct oral anticoagulants are frequently used to treat post-myocardial infarction (MI) left ventricular thrombus (LVT). This study was conducted to evaluate the efficacy and safety of use of apixaban, compared to the standard warfarin therapy, in post-MI LVT.Survival curves are shown for freedom from stroke and systemic embolism (SSE) in patients with left ventricular thrombus after index echocardiogram, Mantel-Byar P < .001. DOAC indicates direct oral anticoagulant.
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Left ventricular thrombus (LVT) is associated with a significant risk of ischemic stroke (IS) and peripheral embolization. Societal guidelines recommend the use of warfarin, with direct oral anticoagulants (DOACs) only for patients unable to tolerate warfarin.The advent of reperfusion therapy and the widespread use of primary percutaneous coronary intervention (PCI) have markedly reduced the incidence of post–myocardial infarction (MI) left ventricular thrombus (LVT) over the last decades (1–3). Left ventricular thrombus (LVT) can be seen as a complication post myocardial infarction (MI) and also in certain non-ischemic cardiomyopathies [1]. Dating back to pre-perfusion era, the incidence of LVT following an MI used to range from 21% to as high as 46% [2, 3, 4]. Current guidelines recommend anticoagulation with a vitamin K antagonist to treat left ventricular (LV) thrombus after myocardial infarction (MI). Data on the use of direct oral anticoagulants (DOACs) in this setting are limited. The aim of the study was to assess the efficacy of apixaban vs. warfarin in treating LV thrombus after MI.
Our results suggest that apixaban is non-inferior to warfarin for treatment of patients with LV thrombus after acute MI with a 20% non-inferiority margin. Apixaban versus warfarin in patients with left ventricular thrombus: a pilot prospective randomized outcome blinded study investigating size reduction or resolution of left ventricular thrombus. J Clin Prev Cardiol 2020;9:150–4.
Of the 514 patients with LV thrombi, 300 received warfarin, while 185 received DOAC therapy. DOAC use was most commonly apixaban (141/185, 76.2%) or rivaroxaban (46/185, 24.9%). Median follow-up was 351 days (interquartile range, [IQR], 51-866 days).Keywords: Apixaban, direct oral anticoagulants, DOACs, left ventricular thrombus, Rivaroxaban, thrombolysis. 1. BACKGROUND. Left ventricular thrombus (LVT) is a common complication following acute myocardial infarction (AMI) with potential for significant morbidity and mortality.
Direct oral anticoagulants are frequently used to treat post-myocardial infarction (MI) left ventricular thrombus (LVT). This study was conducted to evaluate the efficacy and safety of use of apixaban, compared to the standard warfarin therapy, in post-MI LVT.Survival curves are shown for freedom from stroke and systemic embolism (SSE) in patients with left ventricular thrombus after index echocardiogram, Mantel-Byar P < .001. DOAC indicates direct oral anticoagulant.
Left ventricular thrombus (LVT) is associated with a significant risk of ischemic stroke (IS) and peripheral embolization. Societal guidelines recommend the use of warfarin, with direct oral anticoagulants (DOACs) only for patients unable to tolerate warfarin.The advent of reperfusion therapy and the widespread use of primary percutaneous coronary intervention (PCI) have markedly reduced the incidence of post–myocardial infarction (MI) left ventricular thrombus (LVT) over the last decades (1–3). Left ventricular thrombus (LVT) can be seen as a complication post myocardial infarction (MI) and also in certain non-ischemic cardiomyopathies [1]. Dating back to pre-perfusion era, the incidence of LVT following an MI used to range from 21% to as high as 46% [2, 3, 4].
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